GUT HEALTH /

The Bifidobacterium breve bacterium

The Bifidobacterium breve bacterium (B. Breve) has several well-documented benefits, including the ability to balance the intestine’s microbiota, reduce inflammation, and promote neurological and mental health.

Gut & inflammation

In our intestinal system there is a collection of bacteria that make up our intestinal flora, there are both good and bad bacteria. When we don’t take care of our stomach, the bad bacteria take up too much space, which leads to an imbalance in the intestinal flora and inflammation. Over time, this can lead to chronic inflammation, which can be linked to a variety of health problems and diseases. So, to reduce and prevent chronic inflammation, we need to balance and maintain the balance of the intestinal flora. We can do this with an anti-inflammatory diet, exercise, stress management, and by adding lactic acid bacteria and fibre for the stomach. Here we’ve put together research on the bacterium B. Breve and its anti-inflammatory effects. 

 

Anti-inflammatory effects of B. Breve

In studies on mice to test the use of synbiotics against IBD (using Synbiotic2000), the potential of synbiotics, and especially B. Breve, in the treatment of IBD was shown (Cai et al., 2023).

Studies have also looked into the bacterium B. Breve and its anti-inflammatory effects. Among other things, effects such as improved intestinal barrier function and reduced systemic inflammation were seen (Ishii et al. 2021).

Breve in combination with other strains of probiotics has been shown to reduce intestinal inflammation and demonstrate an improved balance in the microbiota. Which in turn has had an effect on inflammatory bowel diseases (Suganya & Koo 2020).

Breve has also been shown to regulate the HPA axis (hypothalamic-pituitary-adrenal axis), which reduces stress markers and improves sleep quality (Lan et al. 2023).

By strengthening the intestinal mucosa, B. breve can help prevent pathogens and toxins from entering the body, which lightens the burden on the immune response (Kwon et al., 2019).

Several studies have shown that B. breve can increase the production of anti-inflammatory cytokines (proteins that, among other things, stimulate the immune system). This contributes to better regulation of inflammatory processes and may reduce the risk of chronic inflammation (Kwon et al., 2019; Matsuoka et al., 2020).

There are several documented results on the bacterium B. Breve having anti-inflammatory effects and how it contributes to improving stomach health.

 

Gut-Brain

The Gut-Brain axis is a communication pathway that exists between the gut and the brain. This takes place via the nervous system, the blood, and the immune system. Our gut microorganisms play an important role in this communication by influencing brain functions and behaviours. Research has found connections between stomach problems and conditions that affect the brain, such as mental and neuro-degenerative diseases. The bacteria in our stomach therefore affect our brain. Below is a compilation of research on the bacterium B. Breve and its neurological and psychological effects.

 

Neurological and psychological effects of B. Breve

Breve has been shown to help with depression and anxiety. Clinical studies have been conducted on patients with depression where B. Breve reduced some symptoms and helped support emotional stability by regulating the metabolism of tryptophan (which can lead to serotonin production) (Tian et al. 2022).

Breve can also contribute toward cognitive improvement. Models of mice with Alzheimer’s disease were able to show that B. Breve reduced brain inflammation and also improved cognitive functions. The increased production of short-chain fatty acids also contributed to modulating the immune response and reducing neuro-inflammation (Kobayashi et al. 2017).

Several studies have also investigated B. Breve and its effects as an adjunctive treatment for ADHD. For example, two different studies on children with ADHD were able to see improved attention and impulsiveness as well as improved concentration and reduced hyperactivity in the children (Wang, LJ, et al. (2024).

In a systematic review of clinical trials, improved cognition and social interaction were also identified when using synbiotics containing B. Breve in patients (Nahidi, M., et al. 2024).

Another study investigated whether B.Breve could affect the microbiome of children with ADHD and showed improved neuro-cognitive function and reduced inflammation in the brain (Checa-Ros, A., et al. 2021).

A significant improvement in hyperactivity and inattentiveness was also shown after treatment with probiotics including B. Breve in a meta-analysis (Liang, SC, et al. 2024).

Overall, there are quite a number of studies that show neurological and psychological effects of B. Breve and the area of Gut-Brain research.

 

Sources

Agrawal, S., et al. (2020). Early Human Development.​ https://www.sciencedirect.com/science/article/abs/pii/S0378378220302954

Cai et al., 2023, Multispecies Synbiotics and DSS-Induced Colitis Study.

Checa-Ros, A., et al. (2021). Nutrients.​ https://www.mdpi.com/2072-6643/13/1/249

Ishii et al. (2021), Biomedicines.

Kobayashi et al. (2017), Scientific Reports​.

Kwon, J., An, D., Shin, H., Kim, S., Kim, J., & Seo, J. (2019). “Probiotic Bifidobacterium breve alleviates intestinal permeability and modulates the inflammatory response in a mouse model of irritable bowel syndrome.” Journal of Microbiology and Biotechnology, 29(5), 725-733.

Lan et al. (2023), Nutrients.

Li et al. (2022), Nutrients.

Liang, S.C., et al. (2024). BJPsych Open. https://www.cambridge.org/core/journals/bjpsych-open/article/therapeutic-efficacy-of-probiotics-for-symptoms-of-attentiondeficit-hyperactivity-disorder-in-children- and-adolescents-metaanalysis/307B11FCC575B8AC36D5249175C8A9CB

Matsuoka, H., Nagai, Y., & Kitaoka, M. (2020). “Bifidobacterium breve supplementation reduces low-grade systemic inflammation and regulates cytokine production in elderly adults.” Journal of Functional Foods, 64, 103605.

Nahidi, M., et al. (2024). Journal of Attention Disorders. https://journals.sagepub.com/doi/abs/10.1177/10870547241228828

Suganya & Koo (2020), International Journal of Molecular Sciences​.

Tian et al. (2022), Brain, Behavior, and Immunity.

Wang, L.J., et al. (2024). Nutrients.​ https://www.mdpi.com/2072-6643/16/14/2260

Xiao et al., 2020, Journal of Alzheimer’s Disease​.

MORE FROM:

Bacteria & fibre for your gut

  • Based on 20 years of research
  • Produced in Sweden
  • Natural - no additives

Get news and tips for your gut flora

Hallo

Det ser ut til at du er i Norge. Besøk vår norske nettside her www.supersynbiotics.no